Macronutrients: All About Fats
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Macronutrients: All About Fats

 Fats are an essential nutrient required for numerous bodily functions such as providing energy, insulating the body, and aiding in the absorption of vitamins.

However, not all fats are created equal, and the types of fats we consume can impact our health. In this article, we will discuss the different types of fats, how they affect our bodies, and how our genes impact our sensitivity to them. 

Types of Fats 

Fats can be divided into four main types: saturated fats, monounsaturated fats, polyunsaturated fats, and trans fats. Saturated fats are found in animal products such as meat and dairy, and can also be found in tropical oils such as coconut and palm oil. Monounsaturated fats are found in plant-based oils such as olive and avocado oil, while polyunsaturated fats are found in fatty fish, nuts, and seeds. Trans fats are artificially created by partially hydrogenating vegetable oils and are found in many processed foods such as baked goods and fried foods. 

How Fats Affect Our Bodies 

Fats play an essential role in many bodily functions, but the type of fat we consume can impact our health. Saturated and trans fats are considered "bad" fats as they raise levels of LDL cholesterol, also known as "bad" cholesterol, which can increase the risk of heart disease and stroke. In contrast, monounsaturated and polyunsaturated fats are considered "good" fats as they can help lower LDL cholesterol levels and reduce the risk of heart disease and stroke. 

Sensitivity to Fats and Genetics 

Genetic sensitivity to fats can impact an individual's performance in several ways. Variations in genes involved in fatty acid metabolism and cholesterol regulation can influence an individual's response to different types of fats, which in turn can impact their health and athletic performance. 

For example, variations in the APOA2 gene have been linked to differences in the response to saturated fat intake (1). Individuals with certain variations in this gene may be more sensitive to saturated fat intake and may experience higher levels of LDL cholesterol, which can increase their risk of developing cardiovascular disease. This sensitivity can impact their athletic performance as cardiovascular disease can limit physical activity and decrease endurance. 

Managing Fat Intake 

While our genes may impact our sensitivity to different types of fats, there are still ways to manage our fat intake to promote good health. Consuming a diet rich in monounsaturated and polyunsaturated fats, such as those found in nuts, seeds, and fatty fish, can help lower LDL cholesterol levels and reduce the risk of heart disease and stroke. It is recommended to limit saturated and trans fats, found in processed foods, red meat, and high-fat dairy, to promote optimal health. 

Conclusion 

Fats are an essential nutrient required for numerous bodily functions. However, not all fats are created equal, and the type of fat we consume can impact our health. Saturated and trans fats are considered "bad" fats, while monounsaturated and polyunsaturated fats are considered "good" fats.

Our genes can influence our sensitivity to different types of fats, and variations in genes involved in fatty acid metabolism and cholesterol regulation have been linked to differences in response to fat intake. By consuming a diet rich in "good" fats and limiting "bad" fats, we can promote optimal health. 

References 

  1. Corella D, Arnett DK, Tucker KL, Kabagambe EK, Tsai M, Parnell LD, Lai CQ, Lee YC, Warodomwichit D, Hopkins PN, Ordovas JM. A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. The Journal of nutrition. 2011 Aug 1;141(8):2219-25. 
  2. Mathias RA, Sergeant S, Ruczinski M, et al. The impact of FADS genetic variants on omega-6 polyunsaturated fatty acid metabolism in African Americans. BMC genetics. 2011 Dec;12(1):50. 
  3. Mozaffarian D, Aro A, Willett WC. Health effects of trans-fatty acids: experimental and observational evidence. European journal of clinical nutrition. 2009 May;63(S2):S5-21. 
  4. Schwingshackl L, Hoffmann G. Monounsaturated fatty acids and risk of cardiovascular disease: synopsis of the evidence available from systematic reviews and meta-analyses. Nutrients. 2012 Aug;4(12):1989-2007. 
  5. Mozaffarian D. Does alpha-linolenic acid intake reduce the risk of coronary heart disease? A review of the evidence. Alternative therapies in health and medicine. 2005 Jan;11(1):24. 
  6. Kris-Etherton PM, Taylor DS, Yu-Poth S, et al. Polyunsaturated fatty acids in the food chain in the United States. The American journal of clinical nutrition. 2000 Jan 1;71(1):179S-88S. 
  7. German JB, Dillard CJ. Saturated fats: what dietary intake?. The American journal of clinical nutrition. 2004 Sep 1;80(3):550-9. 
  8. Li Y, Kilpeläinen TO, Liu C, et al. Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia. 2012 Jul 1;55(4):981-95. 
  9. Heianza Y, Ma W, Huang T, et al. Genetic variants related to glycemic traits and the risk of pancreatic cancer: a Mendelian randomization analysis. Cancer Epidemiology and Prevention Biomarkers. 2020 Apr 1;29(4):811-8. 
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